| BONE HEALTH: Resveratrol and vitamin D influence increased bone density.
Arthritis is a common disease that causes joint pain and loss of mobility, and it is considered a chronic condition that occurs in mature years. Resveratrol can help protect cartilage from degradation34,35, as its breakdown is responsible for joint pain.
Studies have shown that resveratrol consumption affects the increase in bone mineral density36-38, mainly by promoting bone formation or mineralization39. Its action is complemented by vitamin D40.
Vitamin D is a fat-soluble vitamin that plays a crucial role in bone and teeth development. Vitamin D deficiency disrupts calcium metabolism, leading to reduced bone density and an increased risk of fractures and osteoporosis in mature years. Supplementation is particularly recommended for older individuals and during the winter months when vitamin D is not obtained sufficiently from sunlight.
Magnesium is also very important for bone health41, as it participates as a cofactor in hundreds of enzyme systems in the body and is crucial for muscle function and maintaining healthy bones. In fact, more than half of the body's magnesium is found in the bones.
Magnesium is a crucial mineral for athletes as its deficiency can lead to muscle cramps41.
Resveratrol+ contains all the key vitamins and minerals that have been proven to contribute to maintaining healthy bones.
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34. Ali Mobasheri, Yves Henrotin, Hans-Konrad Biesalski and Mehdi Shakibaei: Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health, Int J Mol Sci. 2012; 13(4): 4202–4232
35. N Elmali, O Baysal, A Harma, I Esenkaya, B Mizrak: Effects of resveratrol in inflammatory arthritis. Inflammation, 2007 Apr;30(1-2):1-6. doi: 10.1007/s10753-006-9012-0.
36. Khojah HM, Ahmed S, Abdel-Rahman MS and Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol. 2018; 37(8): 2035-2042.
37. Poulsen MM, Ornstrup MJ, Harsløf T et al. Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phospha- tase in obese non-diabetic men. J Funct Foods. 2014; 6: 305–310.
39. Ornstrup MJ, Harsløf T, Kjaer TN et al. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2014; 99(12): 4720–4729.
40. Feng J, Liu S, Ma S et al. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kB signaling pathway. Acta Biochim Biophys Sin. 2014; 46: 1024–1033.
41. Nacionalni portal o hrani in prehrani RS o magneziju: https://www.prehrana.si/sestavine-zivil/minerali/magnezij?highlight=WyJtYWduZXppaiJd
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| SKIN HEALTH (Anti-aging): Protecting the health of skin cells and enhancing natural skin protection mechanisms.
Pollution and unhealthy habits (poor diet, sun exposure, and smoking) can contribute to oxidative stress and damage the skin. This can lead to age spots, wrinkles, and other forms of irritation, affecting the skin and causing premature aging42.
It also helps protect skin cells from oxidative stress caused by UV light by inhibiting the activity of tyrosinase, a key enzyme involved in melanin synthesis and skin pigmentation44-46.
A clinical trial on 50 healthy women demonstrated that resveratrol:: - significantly reduced systemic oxidative stress and increased skin's antioxidant capacity - improved skin hydration and elasticity and reduced wrinkle depth
- significantly decreased the intensity of age spots47.
Numerous clinical studies have shown that regular use of resveratrol can also impact skin appearance by protecting skin cells and preventing key factors that cause skin aging and damage.
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42. Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012;2012:135206.
43. Farris P et al. Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 2013; 12: 1389- 1394.
44. Britton RG, Kovoor C, and Brown K. Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms. Ann NY Acad Sci. 2015; 1348: 124–133.
45. Bernard P and Berthon J. Resveratrol: an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 2012; 22: 219–226.
46. Buonocore D et al. Resveratrol-procyanidin blend: nutraceutical and anti-aging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 2012; 5: 159–165.
47. Uradna spletna stran podjetja Evolva, ki je proizvajalec Veri-te resveratrola:https://veriteresveratrol.com/benefits/skin-health/ |
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| REDUCED FATIGUE: B-complex is key for improved well-being.
Fatigue or lack of energy is the most common sign of a deficiency in B-complex vitamins in the body. Hair loss, brittle and splitting nails, and frequent mouth ulcers can also be signs of B-vitamin deficiency. Their deficiency can also be linked to depressive mood, anemia, cardiovascular diseases, hormonal imbalances, and insomnia.
B-complex vitamins play a crucial role in times of increased stress, as they help release energy during metabolism, influence our mental capabilities, and contribute to the normal functioning of the nervous system and psychological well-being.
Vitamins B6, B12, B9: contribute to the functioning of the immune system. Vitamins B9, B2: help reduce fatigue and exhaustion. Vitamins B1, B2, B6, B12: contribute to normal psychological function.
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| EYE HEALTH:Prevents age-related eye diseases with its anti-inflammatory action.
Eye diseases are currently a significant public health problem due to the increasing number of cases attributed to aging population and lifestyle-related factors. Many researchers are paying special attention to prevention, where diet plays a predominant role.
The main causes of visual impairment are primarily age-related eye diseases such as age-related macular degeneration (AMD), cataracts, diabetic retinopathy (DR), and glaucoma. Oxidative stress and inflammation play a crucial role in the development and progression of age-related eye diseases, leading to progressive vision loss and blindness 2,4.
Studies have demonstrated that resveratrol, with its anti-inflammatory action, could prevent age-related eye diseases and protect the eyes from environmental factors (such as diabetes, hypertension, stress, UV light, and air pollution)1.
A study conducted in Birmingham confirmed that resveratrol possesses antioxidative, anti-apoptotic, antitumor, anti-inflammatory, anti-angiogenic, and vasorelaxant properties3. They have suggested that there are numerous potential benefits of adding resveratrol to the treatment of various eye diseases.
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1. Dominique Delmas, Clarisse Cornebise, Flavie Courtaut , Jianbo Xiao and Virginie Aires: New Highlights of Resveratrol: A Review of Properties against Ocular Diseases
2. Khaled K. Abu-Amero 1,2, Altaf A. Kondkar 2 and Kakarla V. Chalam 1: Resveratrol and Ophthalmic Diseases. Published: 5 April 2016
3. Christina Bola & Hannah Bartlett & Frank Eperjesi: Resveratrol and the eye: activity and molecular mechanisms, Graefes Arch Clin Exp Ophthalmol (2014)
4. Ali Koskela, Mika Reinisalo, Goran Petrovski, Debasish Sinha, Céline Olmiere, Reijo Karjalainen and Kai Kaarniranta: Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Published: 11 May 2016
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