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CARDIOVASCULAR SYSTEM: Resveratrol with added vitamins and minerals affects heart function.

As we age and experience stress, the cardiovascular system becomes less capable of adapting to normal changes in a body. Maintaining a flexible cardiovascular system1 (heart, arteries, capillaries, and veins) helps to preserve normal blood pressure, blood flow, blood glucose levels, and overall health and well-being.

Systolic blood pressure (SBP) gradually increases with age, leading to artery stiffness. This is considered a significant risk factor for cardiovascular diseases2. Studies from 2015 have shown that resveratrol can help reduce pressure on the artery walls and contribute to improved artery function3-5. It can also support healthy blood flow by dilating blood vessels, which helps maintain proper blood circulation.6,7,8,10.

Omega-3 fatty acids11have been proven to significantly reduce the risk of sudden death due to cardiac arrhythmias. They are also used in the treatment of hyperlipidemia and hypertension.

Magnesium is an essential element that supports normal heart function11. Its deficiency can influence elevated blood pressure and disturbances in heart function.

Infinivit Omega-3 and Resveratrol+ contribute to the healthy functioning of the heart.

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1. Huang H, Chen G, Liao D et al. The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials. Obes Rev. 2016; 17(12): 1329-1340.

2. Strandberg TE and Pitkala K. What is the most important component of blood pressure: systolic, diastolic or pulse pressure? Curr Opin Nephrol Hypertens. 2003; 12(3): 293-297.

3. Timmers S, Konings E, Bilet L et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011; 14(5): 612-622.

4. Movahed A, Nabipour I, Lieben Louis X et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Altern Med. 2013; Article ID 851267, 11 pages.

5. Liu Y, Ma W, Zhang P et al. Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials. Clin Nutr. 2015; 34(1): 27-34.

6. Carrizzo A, Puca A, Damato A et al.
Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism. Hypertension. 2013; 62(2): 359-366.

7. Black CD, Vickerson B and McCully KK. Noninvasive assessment of vascular function in the posterior tibial artery of healthy humans. Dynamic Med. 2003; 2:1.

8. Wong RH, Howe PR, Buckley JD et al. Acute resveratrol supplementation improves flow- mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2011; 21(11): 851- 856.

9. Dominique Bonnefont-Rousselot: Resveratrol and Cardiovascular Diseases, Nutrients: 2016 May 2;8(5):250.

10. Rocío López-Sepúlveda Rosario Jiménez, Miguel Romero, Maria José Zarzuelo, Manuel Sánchez, Manuel Gómez-Guzmán, Félix Vargas, Francisco O'Valle, Antonio Zarzuelo, Francisco Pérez-Vizcaíno, Juan Duarte: Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Pertension, 2008 Apr;51(4):1088-95.

11. Nacionalni portal o hrani in prehrani RS:

COGNITIVE SYSTEM: Maintaining active cognitive function

Several studies have shown that resveratrol can help slow age-related cognitive decline12 in memory, coordination, concentration, and thinking. This is attributed to the antioxidant and anti-inflammatory properties of resveratrol.

Stroke is one of the leading causes of death in the global population. Scientific research indicates that oxidative stress is a predominant factor associated with stroke13,14. Recent data also suggests that resveratrol has the ability to improve the state of oxidative stress in the body (for healthy cell function and metabolism), which may be due to the production of nitric oxide.

Resveratrol is a potent antioxidant and anti-inflammatory compound that has shown great promise in protecting brain cells from damage. Studies have found that regular consumption of resveratrol may help prevent the formation of plaques, which are a hallmark of Alzheimer's disease15,16.

Omega-3 fatty acids are essential nutrients needed for the growth of the brain and retinal tissue for vision. Both contribute to the development of learning and cognitive abilities, thus improving the quality of life.

Vitamin B is an important vitamin that has a proven role in the normal functioning of the nervous system17.

In addition to resveratrol, Resveratrol+ also contains B-complex vitamins, which play a role in the functioning of the nervous system and brain. Omega-3 fatty acids, with a daily dose of at least 250 mg, significantly contribute to the healthy functioning of the heart.

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12. Alberto Granzotto and Paolo Zatta: Resveratrol and Alzheimer’s disease: message in a bottle on red wine and cognition, Front Aging Neurosci. 2014; 6: 95.

13. Charlotte Regitz , Elena Fitzenberger , Friederike Luise Mahn , Lisa Marie Dußling , Uwe Wenzel: Resveratrol reduces amyloid-beta (Aβ₁₋₄₂)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans. Eur J Nutr. . 2016 Mar;55(2):741-747.

14. Weaver J, Liu KJ. Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature. Med Gas Res (2015) 5:015–0032. 10.1186/s13618-015-0032-4

15. Saita E, Kondo K, Momiyama Y. Anti-inflammatory diet for atherosclerosis and coronary artery disease: antioxidant foods. Clin Med Insights Cardiol (2015) 8:61–5. 10.4137/CMC.S17071

16. Nabavi SF, Li H, Daglia M, Nabavi SM. Resveratrol and stroke: from chemistry to medicine. Curr Neurovasc Res (2014) 11:390–7. 10.2174/1567202611666140912114833

17. Nacionalni portal o hrani in prehrani RS:

IMMUNE SYSTEM: The First Defender of Health

Undoubtedly, nutrition is a key factor in maintaining good health. Vitamins and minerals such as C, D1, E, zinc, and omega-3 fatty acids have well-established effects on our immune system19.

Vitamin C intake is often associated with beneficial effects on the immune system. Vitamin C deficiency leads to weakened immunity and increased susceptibility to infections18.

Vitamin D has been shown to play a crucial role in bone density and is essential for the immune system20,21. Vitamin D deficiency is linked to increased autoimmunity and susceptibility to infections. Additionally, it is known to have an antioxidant role, protecting the body's structures from oxidative stress.

Magnesium levels are also vital for the immune system21, as its deficiency can impact the functioning of vitamin D and affect infection risk.

Resveratrol+ includes vitamins C, D, and magnesium, which have been proven to significantly influence and strengthen our immune system. A robust immune system is crucial for health as it protects our bodies from infections.

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18. Anitra C Carr , Silvia Maggini: Vitamin C and Immune Function, Review Nutrients. 2017 Nov 3;9(11):1211.

19. Cynthia Aranow: Vitamin D and the Immune System, J Investig Med. 2011 Aug; 59(6): 881–886.

20. Christopher Weyh, Karsten Krüger, Peter Peeling and Lindy Castell: The Role of Minerals in the Optimal Functioning of the Immune System, Nutrients. 2022 Feb; 14(3): 644.

21. Nacionalni portal o hrani in prehrani RS:

BONE HEALTH: Resveratrol and vitamin D influence increased bone density.

Arthritis is a common disease that causes joint pain and loss of mobility, and it is considered a chronic condition that occurs in mature years. Resveratrol can help protect cartilage from degradation34,35, as its breakdown is responsible for joint pain.

Studies have shown that resveratrol consumption affects the increase in bone mineral density36-38, mainly by promoting bone formation or mineralization39. Its action is complemented by vitamin D40.

Vitamin D is a fat-soluble vitamin that plays a crucial role in bone and teeth development. Vitamin D deficiency disrupts calcium metabolism, leading to reduced bone density and an increased risk of fractures and osteoporosis in mature years. Supplementation is particularly recommended for older individuals and during the winter months when vitamin D is not obtained sufficiently from sunlight.

Magnesium is also very important for bone health41, as it participates as a cofactor in hundreds of enzyme systems in the body and is crucial for muscle function and maintaining healthy bones. In fact, more than half of the body's magnesium is found in the bones.

Magnesium is a crucial mineral for athletes as its deficiency can lead to muscle cramps41.

Resveratrol+ contains all the key vitamins and minerals that have been proven to contribute to maintaining healthy bones.

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34. Ali Mobasheri, Yves Henrotin, Hans-Konrad Biesalski and Mehdi Shakibaei: Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health, Int J Mol Sci. 2012; 13(4): 4202–4232

35. N Elmali, O Baysal, A Harma, I Esenkaya, B Mizrak: Effects of resveratrol in inflammatory arthritis. Inflammation, 2007 Apr;30(1-2):1-6. doi: 10.1007/s10753-006-9012-0.

36. Khojah HM, Ahmed S, Abdel-Rahman MS and Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol. 2018; 37(8): 2035-2042.

37. Poulsen MM, Ornstrup MJ, Harsløf T et al. Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phospha- tase in obese non-diabetic men. J Funct Foods. 2014; 6: 305–310.

39. Ornstrup MJ, Harsløf T, Kjaer TN et al. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2014; 99(12): 4720–4729.

40. Feng J, Liu S, Ma S et al. Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-kB signaling pathway. Acta Biochim Biophys Sin. 2014; 46: 1024–1033.

41. Nacionalni portal o hrani in prehrani RS o magneziju:

SKIN HEALTH (Anti-aging): Protecting the health of skin cells and enhancing natural skin protection mechanisms.

Pollution and unhealthy habits (poor diet, sun exposure, and smoking) can contribute to oxidative stress and damage the skin. This can lead to age spots, wrinkles, and other forms of irritation, affecting the skin and causing premature aging42.

It also helps protect skin cells from oxidative stress caused by UV light by inhibiting the activity of tyrosinase, a key enzyme involved in melanin synthesis and skin pigmentation44-46.

A clinical trial on 50 healthy women demonstrated that resveratrol::
- significantly reduced systemic oxidative stress and increased skin's antioxidant capacity
- improved skin hydration and elasticity and reduced wrinkle depth
- significantly decreased the intensity of age spots47.

Numerous clinical studies have shown that regular use of resveratrol can also impact skin appearance by protecting skin cells and preventing key factors that cause skin aging and damage.

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42. Poljšak B and Dahmane R. Free Radicals and Extrinsic Skin Aging. Dermatol Res Pract. 2012;2012:135206.

43. Farris P et al. Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin. J Drugs Dermatol. 2013; 12: 1389- 1394.

44. Britton RG, Kovoor C, and Brown K. Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms. Ann NY Acad Sci. 2015; 1348: 124–133.

45. Bernard P and Berthon J. Resveratrol: an original mechanism on tyrosinase inhibition. Int J Cosmet Sci. 2012; 22: 219–226.

46. Buonocore D et al. Resveratrol-procyanidin blend: nutraceutical and anti-aging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 2012; 5: 159–165.

47. Uradna spletna stran podjetja Evolva, ki je proizvajalec Veri-te resveratrola:

REDUCED FATIGUE: B-complex is key for improved well-being.

Fatigue or lack of energy is the most common sign of a deficiency in B-complex vitamins in the body. Hair loss, brittle and splitting nails, and frequent mouth ulcers can also be signs of B-vitamin deficiency. Their deficiency can also be linked to depressive mood, anemia, cardiovascular diseases, hormonal imbalances, and insomnia.

B-complex vitamins play a crucial role in times of increased stress, as they help release energy during metabolism, influence our mental capabilities, and contribute to the normal functioning of the nervous system and psychological well-being.

Vitamins B6, B12, B9: contribute to the functioning of the immune system.
Vitamins B9, B2: help reduce fatigue and exhaustion.
Vitamins B1, B2, B6, B12: contribute to normal psychological function.

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Nacionalni portal o hrani in prehrani RS:

EYE HEALTH:Prevents age-related eye diseases with its anti-inflammatory action.

Eye diseases are currently a significant public health problem due to the increasing number of cases attributed to aging population and lifestyle-related factors. Many researchers are paying special attention to prevention, where diet plays a predominant role.

The main causes of visual impairment are primarily age-related eye diseases such as age-related macular degeneration (AMD), cataracts, diabetic retinopathy (DR), and glaucoma. Oxidative stress and inflammation play a crucial role in the development and progression of age-related eye diseases, leading to progressive vision loss and blindness 2,4.

Studies have demonstrated that resveratrol, with its anti-inflammatory action, could prevent age-related eye diseases and protect the eyes from environmental factors (such as diabetes, hypertension, stress, UV light, and air pollution)1.

A study conducted in Birmingham confirmed that resveratrol possesses antioxidative, anti-apoptotic, antitumor, anti-inflammatory, anti-angiogenic, and vasorelaxant properties3. They have suggested that there are numerous potential benefits of adding resveratrol to the treatment of various eye diseases.

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1. Dominique Delmas, Clarisse Cornebise, Flavie Courtaut , Jianbo Xiao and Virginie Aires: New Highlights of Resveratrol: A Review of Properties against Ocular Diseases

2. Khaled K. Abu-Amero 1,2, Altaf A. Kondkar 2 and Kakarla V. Chalam 1: Resveratrol and Ophthalmic Diseases. Published: 5 April 2016

3. Christina Bola & Hannah Bartlett & Frank Eperjesi: Resveratrol and the eye: activity and molecular mechanisms, Graefes Arch Clin Exp Ophthalmol (2014)

4. Ali Koskela, Mika Reinisalo, Goran Petrovski, Debasish Sinha, Céline Olmiere, Reijo Karjalainen and Kai Kaarniranta: Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Published: 11 May 2016


A study conducted in Florida, United States, focused on the effects of omega-3 fatty acids and resveratrol in preventing cardiovascular diseases22. Oxidative stress is considered one of the most important factors in various cardiovascular diseases. Scientific research indicates that oxidative stress is a predominant factor associated with stroke23,24.

Recent data also suggests that the ability of resveratrol to improve oxidative stress is linked to its anti-inflammatory activity25. Resveratrol has demonstrated strong antioxidant properties, providing significant protection for heart health. Numerous studies have shown that the consumption of Mediterranean diet, rich in omega-3 fatty acids 26-28and plant phenols (resveratrol)30, reduces the risk of cardiovascular diseases, hypertension, stroke, and their complications.

Both resveratrol and omega-3 have been proven to play a crucial role in protecting against cardiovascular diseases31 and various other conditions, including Alzheimer's disease, cancer, diabetes, and inflammation. Numerous studies have found that the intake of omega-3 and resveratrol has synergistic effects32,33, and their actions efficiently complement each other.

22. Basu A, Devaraj S, Jialal I. Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol (2006) 26:995–1001. 10.1161/01.ATV.0000214295.86079.d1

23. Weaver J, Liu KJ. Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature. Med Gas Res (2015)

24. Saita E, Kondo K, Momiyama Y. Anti-inflammatory diet for atherosclerosis and coronary artery disease: antioxidant foods. Clin Med Insights Cardiol (2015)

25. Nabavi SF, Li H, Daglia M, Nabavi SM. Resveratrol and stroke: from chemistry to medicine. Curr Neurovasc Res (2014) 11:390–7.

27. Buckley JD, Howe PR. Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity – a review. Nutrients (2010) 2:1212–30. 10.3390/nu2121212

28. Bourre JM. Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing. J Nutr Health Aging (2004) 8:163–74. 10.1186/1476-511X-3-25

29. Holman RT. The slow discovery of the importance of omega 3 essential fatty acids in human health. J Nutr (1998) 128:427S–33S.

30. WHO. Interventions on Diet and Physical Activity: What Works: Summary Report. Geneva: World Health Organization; (2009).

31. Huhn S, Kharabian Masouleh S, Stumvoll M, Villringer A, Witte AV. Components of a Mediterranean diet and their impact on cognitive functions in aging. Front Aging Neurosci (2015)

32. Couto E, Boffetta P, Lagiou P, Ferrari P, Buckland G, Overvad K, et al. Mediterranean dietary pattern and cancer risk in the EPIC cohort. Br J Cancer (2011) 104:1493–9.

33. Lopez-Garcia E, Rodriguez-Artalejo F, Li TY, Fung TT, Li S, Willett WC, et al. The Mediterranean-style dietary pattern and mortality among men and women with cardiovascular disease. Am J Clin Nutr (2014)

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